Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 8/20 | 1.00 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153583 | 0.91 | SMPD3 (0.84) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL22301647 | 0.89 | SMPD3 (1.00) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL6465442 | 0.88 | NOX1 (0.81) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL12601823 | 0.88 | SMPD3 (0.79) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL12958682 | 0.88 | SMPD3 (1.00) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL11595659 | 0.86 | SMPD3 (0.76) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL6465425 | 0.86 | SMPD3 (0.76) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL175592 | 0.86 | SMPD3 (0.75) | SMPD3NOX1MAPTTP53MEN1 | |
| Hydrochloric Acid SCHEMBL9648176 | 0.85 | SMPD3 (0.73) | SMPD3NOX1MAPTTP53MEN1 | |
| SCHEMBL8008805 | 0.84 | NOX1 (0.85) | SMPD3NOX1MAPTTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347139-A2 | Imidazole leuco dye composition containing 4'-hydroxyacetanilide diagnostic kit and method using same | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-12-20 | — | — | EP | claimed |
| US-4089747-A | OXIDATION OF DYE-PROVIDING MATERIALS, A SULFONYL HYDRAZONE AND A COUPLER OR A TRIARYLIMIDAZOLE | EASTMAN KODAK COMPANY (US) | 1978-05-16 | — | — | US | claimed |
| US-20220119374-A1 | SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2022-04-21 | — | — | US | disclosed |
| EP-3917530-A1 | SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) INHIBITORS | The Johns Hopkins University (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160148-A1 | SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160148-A1 | SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-08-06 | — | — | WO | disclosed |
| EP-0511712-B2 | Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle | JOHNSON & JOHNSON CLIN DIAG (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6645758-B1 | Polymerase Chain Reaction (PCR); use when reactions are undertaken to amplify and detect nucleic acids, using PCR technology, without exposing the environment to amplified nucleic acid | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. | 2003-11-11 | — | — | US | disclosed |
| US-6475729-B1 | Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. | 2002-11-05 | — | — | US | disclosed |
| EP-0603954-B1 | Immunoassay using a 4-hydroxy or 4-alkoxyarylacetamide as stabilizer | JOHNSON & JOHNSON CLIN DIAG (US) | 2000-03-08 | — | — | EP | disclosed |
| US-5888723-A | SENSITIVE HYBRIDIZATION ASSAY USING NUCLEIC ACID REAGENT COMPOSED OF OLIGONUCLEOTIDES COVALENTLY ATTACHED TO POLYMER PARTICLES WHICH ARE ADHERED TO SUPPORT USING WATER INSOLUBLE ADHESIVE; LOW BACKGROUND | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| WO-1989009939-A1 | COMPOSITIONS, DIAGNOSTIC KIT AND METHOD FOR RAPID DETECTION OF ANTIBODIES | EASTMAN KODAK COMPANY (US) | 1989-10-19 | — | — | WO | disclosed |
| EP-0337785-A1 | Diagnostic kit and method for rapid detection of antibodies | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1989-10-18 | — | — | EP | disclosed |
| US-4870007-A | DIAGNOSIS OF PREGNANCY | EASTMAN KODAK COMPANY (US) | 1989-09-26 | — | — | US | disclosed |
| EP-0328413-A2 | Sodium decyl sulfate wash solution, test kit and method for the determination of an immunological ligand | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-08-16 | — | — | EP | disclosed |
| EP-0328388-A2 | Wash solution, test kit and method for the determination of an immunological ligand | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-08-16 | — | — | EP | disclosed |
| EP-0321261-A1 | Use of immobilized biotinylated receptor in test device, kit and method for determining a ligand | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-06-21 | — | — | EP | disclosed |
| EP-0318255-A2 | Cuvette | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0308236-A2 | Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1989-03-22 | — | — | EP | disclosed |
| EP-0302715-A1 | Avidin- and biotin-immobilized reagents, analytical elements and methods of use | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1989-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119374-A1 | SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS | SMPD2, SPTLC2, SGMS2 | SMPD3 8/4885NOX1 2182/4885MAPT 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.