Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 7/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845762 | 0.82 | BCHE (0.47) | EPHX2ACHE | |
| SCHEMBL9154495 | 0.78 | EPHX2 (0.42) | EPHX2ACHEKDM1AMAOB | |
| SCHEMBL16494321 | 0.73 | ACHE (0.55) | ACHE | |
| SCHEMBL16495028 | 0.71 | ACHE (0.56) | EPHX2ACHE | |
| SCHEMBL16494085 | 0.71 | BCHE (0.59) | ACHE | |
| SCHEMBL16494711 | 0.70 | ACHE (0.62) | EPHX2ACHE | |
| SCHEMBL8845548 | 0.69 | ACHE (0.51) | ACHEHDAC6 | |
| SCHEMBL16494443 | 0.69 | ACHE (0.60) | EPHX2ACHE | |
| SCHEMBL8846256 | 0.68 | TP53 (0.43) | — | |
| SCHEMBL8846262 | 0.67 | ACHE (0.43) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5455245-A | Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5264442-A | For treating alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0471298-A1 | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |