Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9152666 | 0.82 | FAAH (0.43) | ACHE | |
| SCHEMBL9154489 | 0.78 | EPHX2 (0.44) | EPHX2ACHEKDM1AMAOB | |
| SCHEMBL9152706 | 0.75 | ACHE (0.42) | TP53HRH3BCHEACHESMN1; SMN2 | |
| SCHEMBL9158206 | 0.69 | LIPE (0.41) | TP53BCHEACHE | |
| SCHEMBL27233641 | 0.67 | SMN1; SMN2 (0.61) | EPHX2KDM1AMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL27233628 | 0.67 | SMN1; SMN2 (0.61) | EPHX2KDM1AMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL27164915 | 0.67 | SMN1; SMN2 (0.61) | EPHX2KDM1AMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL27233621 | 0.67 | SMN1; SMN2 (0.61) | EPHX2KDM1AMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL27234544 | 0.67 | SMN1; SMN2 (0.61) | EPHX2KDM1AMAOBSMN1; SMN2NPSR1 | |
| SCHEMBL27233569 | 0.67 | SMN1; SMN2 (0.61) | EPHX2KDM1AMAOBSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471298-B1 | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST ROUSSEL PHARMA (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5455245-A | Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5264442-A | For treating alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0471298-A1 | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |