Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.30 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9161176 | 0.90 | GRM4 (0.39) | GRM4TLR8ALOX5 | |
| SCHEMBL9161437 | 0.87 | GRM4 (0.39) | GRM4TLR8ALOX5 | |
| SCHEMBL9258559 | 0.83 | MAOB (0.48) | — | |
| SCHEMBL9157666 | 0.80 | ALOX5 (0.39) | ALOX5 | |
| SCHEMBL9154667 | 0.77 | ALOX5 (0.39) | ALOX5PARP14 | |
| SCHEMBL9159680 | 0.77 | ALOX5 (0.39) | ALOX5PARP14 | |
| SCHEMBL9159702 | 0.77 | GRM4 (0.40) | GRM4TLR8ALOX5 | |
| SCHEMBL9160050 | 0.76 | ALOX5 (0.41) | ALOX5PARP14 | |
| SCHEMBL9263552 | 0.76 | MAOB (0.47) | — | |
| SCHEMBL9268130 | 0.75 | MAOB (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5410054-A | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1995-04-25 | — | — | US | disclosed |
| WO-1995003300-A1 | HETEROARYL QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1995-02-02 | — | — | WO | disclosed |