Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | APEX1 | P27695 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD5 | P21918 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9151954 | 0.84 | MAPT (0.50) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| SCHEMBL10606400 | 0.84 | TSHR (0.40) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| SCHEMBL9156756 | 0.83 | TSHR (0.61) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| Hydrochloric Acid SCHEMBL9152256 | 0.81 | LMNA (0.62) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| SCHEMBL9155889 | 0.78 | TSHR (0.44) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| SCHEMBL10600900 | 0.75 | ADRB2 (0.60) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| Hydrochloric Acid SCHEMBL11548357 | 0.75 | LMNA (0.71) | TSHRCYP1A2CYP3A4NFKB1LMNA | |
| SCHEMBL9150874 | 0.74 | MAPT (0.41) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL9155909 | 0.74 | SMN1; SMN2 (0.45) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL29351790 | 0.73 | TSHR (1.00) | TSHRCYP1A2CYP3A4NFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167204-B1 | METHOD FOR IMPROVING THE ABSORPTION AND EFFECTIVENESS OF A CATECHOLAMINE COMPOUND | SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) | 1989-09-27 | — | — | EP | claimed |
| US-4673671-A | CONVERSION TO MONO O-PHOSPHATE ESTER | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1987-06-16 | — | — | US | claimed |
| EP-0430336-B1 | Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives | ZAMBON SPA (IT) | 1995-02-15 | — | — | EP | disclosed |
| US-5138084-A | PROCESS FOR THE PREPARATION OF 4-O-PHOSPHATES OF DOPAMINE AND DOPAMINE DERIVATIVES | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-08-11 | — | — | US | disclosed |
| EP-0430336-A2 | Process for the preparation of 4-O-phosphates of dopamine and dopamine derivatives | ZAMBON GROUP S.p.A. (IT) | 1991-06-05 | — | — | EP | disclosed |
| EP-0167204-B1 | METHOD FOR IMPROVING THE ABSORPTION AND EFFECTIVENESS OF A CATECHOLAMINE COMPOUND | SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) | 1989-09-27 | — | — | EP | disclosed |
| US-4673671-A | CONVERSION TO MONO O-PHOSPHATE ESTER | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1987-06-16 | — | — | US | disclosed |