Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CCR6 | P51684 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536279 | 0.85 | HTR1A (0.58) | HTR1AHTTKMT2ADRD2HTR2A | |
| SCHEMBL29932017 | 0.85 | HTR1A (0.58) | HTR1AHTTKMT2ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL31232826 | 0.84 | HTR1A (0.57) | HTR1AHTTKMT2ADRD2HTR2A | |
| SCHEMBL1274938 | 0.84 | HTT (0.73) | HTR1AHTTKMT2AMITFALDH1A1 | |
| SCHEMBL8828404 | 0.83 | DRD2 (0.59) | HTR1AHTTKMT2ADRD2HTR2A | |
| SCHEMBL27351820 | 0.83 | DRD2 (0.58) | HTR1AHTTKMT2ADRD2HTR2A | |
| SCHEMBL4520581 | 0.82 | KMT2A (0.61) | HTR1AHTTKMT2ADRD2MITF | |
| SCHEMBL24629113 | 0.82 | HTR1A (0.58) | HTR1AHTTKMT2ADRD2HTR2A | |
| SCHEMBL3210395 | 0.82 | DRD2 (0.60) | HTR1AHTTKMT2ADRD2HTR2A | |
| SCHEMBL18118448 | 0.82 | DRD2 (0.58) | HTR1AHTTKMT2ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405847-A | Antiallergic, antiasthmatic, anxiolytic, hypotensive agents | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |
| EP-0584487-A2 | 4,5-Dihydro-4-oxopyrrolo (1,2-a) quinoxalines and aza-analoges and process for their preparation | ASTA Medica Aktiengesellschaft (DE) | 1994-03-02 | — | — | EP | disclosed |