Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.72 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16994453 | 0.93 | SIGMAR1 (0.73) | SIGMAR1AOC3MAOASLC6A2SLC6A4 | |
| SCHEMBL8828390 | 0.92 | SIGMAR1 (0.70) | SIGMAR1AOC3MAOASLC6A2SLC6A4 | |
| SCHEMBL11104325 | 0.92 | SIGMAR1 (0.72) | SIGMAR1AOC3MAOASLC6A2SLC6A4 | |
| SCHEMBL12902332 | 0.90 | SIGMAR1 (0.88) | SIGMAR1AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9155641 | 0.87 | SIGMAR1 (0.73) | SIGMAR1AOC3MAOASLC6A2SLC6A4 | |
| SCHEMBL11133953 | 0.86 | SIGMAR1 (0.96) | SIGMAR1AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8096630 | 0.84 | SIGMAR1 (1.00) | SIGMAR1AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10936647 | 0.83 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL8630352 | 0.83 | SIGMAR1 (0.62) | SIGMAR1AOC3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2108172 | 0.82 | CARM1 (0.78) | SIGMAR1AOC3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| CN-1223659-A | Fused imidazopyridine derivatives as antihyperlipidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |