SCHEMBL9156589

SCHEMBL9156589

BrC(C=Cc1ccccc1)=Cc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.52
MAPT P10636 3/20 0.52
RECQL P46063 3/20 0.52
ALDH1A1 P00352 3/20 0.52
HDAC3 O15379 2/20 0.52
HDAC4 P56524 2/20 0.52
HDAC1 Q13547 2/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
PLIN1 O60240 2/20 0.52
PLIN5 Q00G26 2/20 0.52
ABHD5 Q8WTS1 2/20 0.52
TNKS O95271 1/20 0.52
HCAR2 Q8TDS4 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
TNKS2 Q9H2K2 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6212312 0.90 CYP1B1 (0.54) LMNAMAPTRECQLALDH1A1HDAC3
SCHEMBL708707 0.79 NPC1 (0.50) LMNAMAPTRECQLALDH1A1TDP1
SCHEMBL708706 0.79 NPC1 (0.50) LMNAMAPTRECQLALDH1A1TDP1
SCHEMBL9067969 0.77 MAPT (0.41) LMNAMAPTRECQLALDH1A1SMN1; SMN2
SCHEMBL29466710 0.76 MAPT (0.56) LMNAMAPTRECQLALDH1A1HDAC3
SCHEMBL29670874 0.76 MAPT (0.56) LMNAMAPTRECQLALDH1A1HDAC3
SCHEMBL546104 0.76 MAPT (0.56) LMNAMAPTRECQLALDH1A1HDAC3
SCHEMBL30688107 0.75
SCHEMBL567062 0.74 ALDH1A1 (0.56) LMNAMAPTRECQLALDH1A1TDP1
SCHEMBL1552546 0.74 ALDH1A1 (0.56) LMNAMAPTRECQLALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4028465-A1 HIGH-VOLTAGE COMPONENTS LANXESS Deutschland GmbH (DE) 2022-07-20 EP disclosed
EP-4028464-A1 HIGH-VOLTAGE COMPONENTS LANXESS Deutschland GmbH (DE) 2022-07-20 EP disclosed
US-5426149-A Blend of epoxy modified styrene-styrene copolymer, conjugated diene-styrene copolymer with glass fiber reinforcement PHILLIPS PETROLEUM COMPANY (US) 1995-06-20 US disclosed
EP-0368237-B1 Polymer bound flame retardants ATOCHEM NORTH AMERICA (US) 1995-04-12 EP disclosed
US-5220015-A Having hydrazide group to chemically bond to anhydride-containing polymers ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-06-15 US disclosed
US-5140070-A Halogenated aromatic compounds having acylamino functional groups bonded to imide containing polymer ELF ATOCHEM NORTH AMERICA, INC (US) 1992-08-18 US disclosed
EP-0195815-B1 FUNCTIONALIZED POLYPHENYLENE ETHERS AND BLENDS WITH POLYAMIDES GENERAL ELECTRIC COMPANY (US) 1991-12-11 EP disclosed
US-5069818-A CHEMICAL RESISTANCE, IMPACT STRENGTH GENERAL ELECTRIC COMPANY (US) 1991-12-03 US disclosed
US-5037894-A Maleic anhydride polymer reacted with halogenated hydrazide compound or derivative ATOCHEM NORTH AMERICA, INC. (US) 1991-08-06 US disclosed
EP-0436136-A1 Compatibilized polyphenylene ehter resin/nylon resin blends containing aromatic phosphorous-containing compounds GENERAL ELECTRIC COMPANY (US) 1991-07-10 EP disclosed
US-4164493-A MOLDING MATERIALS, IMPACT STRENGTH GENERAL ELECTRIC COMPANY (US) 1979-08-14 US disclosed
US-4154719-A ALKENYL AROMATIC RESIN MODIFIED WITH A DIENE RUBBER GENERAL ELECTRIC COMPANY (US) 1979-05-15 US disclosed
US-4152316-A COMPOSITIONS OF A POLYPHENYLENE ETHER RESIN AND ALKENYL AROMATIC RESINS MODIFIED WITH EPDM RUBBER GENERAL ELECTRIC COMPANY (US) 1979-05-01 US disclosed
US-4143095-A MOLDING MATERIALS GENERAL ELECTRIC COMPANY (US) 1979-03-06 US disclosed
US-4139574-A Impact resistant polyphenylene ether resin compositions containing EPDM rubber-modified alkenyl aromatic resins and hydrogenated radial teleblock copolymers GENERAL ELECTRIC COMPANY (US) 1979-02-13 US disclosed
US-4127558-A Compositions of a polyphenylene ether resin and alkenyl aromatic resins modified with EPDM rubber containing propylene GENERAL ELECTRIC COMPANY (US) 1978-11-28 US disclosed
US-4102850-A MONO-OLEFIN-POLYENE MODIFIED ALKENYL AROMATIC RESIN GENERAL ELECTRIC COMPANY (US) 1978-07-25 US disclosed
US-4101505-A Compositions of a polyphenylene ether resin and EPDM rubber-modified alkenyl aromatic resins having specified gel content GENERAL ELECTRIC COMPANY (US) 1978-07-18 US disclosed
US-4101503-A Compositions of a polyphenylene ether resin and high molecular weight alkenyl aromatic resins modified with EPDM rubber GENERAL ELECTRIC COMPANY (US) 1978-07-18 US disclosed
US-4101504-A High impact compositions of a polyphenylene ether resin and alkenyl aromatic resins modified with EPDM rubber GENERAL ELECTRIC COMPANY (US) 1978-07-18 US disclosed