Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 12/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711429 | 0.82 | HPN (0.41) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9680931 | 0.80 | VCAM1 (0.40) | VCAM1GPR55HPNMAPTALOX15 | |
| SCHEMBL9160161 | 0.80 | VCAM1 (0.57) | VCAM1GPR55HPNMAPTALOX15 | |
| SCHEMBL9345621 | 0.79 | GAA (0.35) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL10356729 | 0.79 | VCAM1 (0.39) | VCAM1GPR55HPNMAPTALOX15 | |
| SCHEMBL9682698 | 0.77 | VCAM1 (0.38) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9157478 | 0.77 | TDP1 (0.44) | TDP1 | |
| SCHEMBL9621875 | 0.76 | VCAM1 (0.43) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL6438215 | 0.76 | VCAM1 (0.48) | VCAM1GPR55HPNMAPTALOX15 | |
| SCHEMBL29638845 | 0.76 | VCAM1 (0.48) | VCAM1GPR55HPNMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064860-A | Disease therapy | G. D. SEARLE & CO. (US) | 1991-11-12 | — | — | US | claimed |
| US-4755524-A | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1988-07-05 | — | — | US | claimed |
| EP-0547090-B1 | PHENOLIC THIOETHERAMIDES AS 5-LIPOXYGENASE INHIBITORS | SEARLE & CO (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5326907-A | 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers | G. D. SEARLE & CO. (US) | 1994-07-05 | — | — | US | disclosed |
| WO-1993010087-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |
| WO-1992019608-A2 | CYCLIC PHENOLIC THIOETHERS | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| WO-1992019591-A1 | PROCESS FOR PREPARATION OF ALPHA-ALKOXY ACETIC ACIDS AND THEIR SALTS | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512472-A1 | Process for preparation of alpha-alkoxy acetic acids and their salts | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-5145992-A | Oxyalkylation of an alcohol, reaction with monoaloacetic acid and then with hydrochloic acid | G. D. SEARLE & CO. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5064860-A | Disease therapy | G. D. SEARLE & CO. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0434896-A1 | Process for preparation of alpha-alkoxy acetic acids and their salts | G.D. Searle & Co. (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5013864-A | From alcohol and haloacetic acid salt | G. D. SEARLE & CO. (US) | 1991-05-07 | — | — | US | disclosed |
| US-4755524-A | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1988-07-05 | — | — | US | disclosed |