Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 12/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.37 |
| ▸ | GLRB | P48167 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9492905 | 0.84 | ALOX15 (0.47) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9168126 | 0.81 | ALOX15 (0.50) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9701236 | 0.81 | ALOX15 (0.44) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9328163 | 0.79 | HPN (0.47) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL10682020 | 0.78 | HPN (0.44) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9680931 | 0.77 | VCAM1 (0.40) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9621401 | 0.76 | VCAM1 (0.52) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9158352 | 0.76 | VCAM1 (0.46) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL10356729 | 0.76 | VCAM1 (0.39) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9711429 | 0.76 | HPN (0.41) | VCAM1MAPTHPNALOX15SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4801611-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1989-01-31 | — | — | US | claimed |
| US-5162365-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5036105-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4801611-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1989-01-31 | — | — | US | disclosed |