Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 13/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682698 | 0.91 | VCAM1 (0.38) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9680931 | 0.84 | VCAM1 (0.40) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9158352 | 0.79 | VCAM1 (0.46) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9711429 | 0.79 | HPN (0.41) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9621875 | 0.76 | VCAM1 (0.43) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL10681572 | 0.74 | HPN (0.41) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9168126 | 0.73 | ALOX15 (0.50) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9701565 | 0.73 | HPN (0.44) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9701236 | 0.73 | ALOX15 (0.44) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL10682020 | 0.73 | HPN (0.44) | VCAM1HPNMAPTALOX15SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235575-B1 | NOVEL PHENOLIC THIOETHERS AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1990-09-19 | — | — | EP | disclosed |
| US-4755524-A | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1988-07-05 | — | — | US | disclosed |