SCHEMBL9158447

SCHEMBL9158447

CCOc1ccc([C@H]2CC[C@H](CCc3ccc(F)nc3)CC2)cc1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.38
RAB9A P51151 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CACNA2D1 P54289 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNA1H O95180 1/20 0.35
CACNA1I Q9P0X4 1/20 0.35
CYP2C9 P11712 1/20 0.34
RORC P51449 1/20 0.34
ACACB O00763 1/20 0.34
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
ESR2 Q92731 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9158454 1.00 MAPT (0.38) MAPTRAB9AL3MBTL1CACNA2D1CACNA1G
SCHEMBL9160931 0.91 ACACB (0.38) MAPTRAB9AL3MBTL1CYP2C9ACACB
SCHEMBL9159166 0.91 RAB9A (0.41) MAPTRAB9AL3MBTL1CYP2C9ALDH1A1
SCHEMBL9160937 0.91 ACACB (0.38) MAPTRAB9AL3MBTL1CYP2C9ACACB
SCHEMBL9159174 0.91 RAB9A (0.41) MAPTRAB9AL3MBTL1CYP2C9ALDH1A1
SCHEMBL9766712 0.89 SPHK1 (0.40) MAPTRAB9AL3MBTL1CYP2C9LMNA
SCHEMBL9158838 0.89 SPHK1 (0.40) MAPTRAB9AL3MBTL1CYP2C9LMNA
SCHEMBL9158847 0.89 SPHK1 (0.40) MAPTRAB9AL3MBTL1CYP2C9LMNA
SCHEMBL9875473 0.86 RAB9A (0.38) MAPTRAB9AL3MBTL1CYP2C9LMNA
SCHEMBL9875481 0.86 RAB9A (0.38) MAPTRAB9AL3MBTL1CYP2C9LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0445248-B1 PYRIDINE DERIVATIVES MERCK PATENT GMBH (DE) 1995-03-08 EP disclosed
US-5205962-A Stable liquid crystals MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-04-27 US disclosed
WO-1991004248-A1 PYRIDINE DERIVATIVES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1991-04-04 WO disclosed