Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.81 |
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | DRD1 | P21728 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9281388 | 0.90 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD4 | |
| SCHEMBL9164109 | 0.88 | SIGMAR1 (1.00) | SIGMAR1DRD3DRD2 | |
| SCHEMBL9165576 | 0.87 | SIGMAR1 (1.00) | SIGMAR1DRD3DRD2DRD4 | |
| SCHEMBL9281346 | 0.81 | SIGMAR1 (0.85) | SIGMAR1 | |
| SCHEMBL14290661 | 0.79 | ABCB1 (0.79) | SIGMAR1 | |
| SCHEMBL2952166 | 0.79 | SIGMAR1 (0.71) | SIGMAR1 | |
| SCHEMBL6526368 | 0.78 | DRD2 (0.85) | DRD3DRD2 | |
| SCHEMBL11088215 | 0.77 | SIGMAR1 (0.71) | SIGMAR1DRD3DRD2 | |
| SCHEMBL9161518 | 0.77 | SIGMAR1 (1.00) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11084488 | 0.77 | SIGMAR1 (0.70) | SIGMAR1DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | claimed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | claimed |
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | disclosed |