⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9651659 | 1.00 | — | — | |
| SCHEMBL9375381 | 0.99 | KDM4E (0.55) | — | |
| SCHEMBL9347959 | 0.87 | MAPK14 (0.56) | — | |
| SCHEMBL9666422 | 0.85 | KDM4E (0.66) | — | |
| SCHEMBL8112795 | 0.85 | KDM4E (0.66) | — | |
| SCHEMBL9651625 | 0.85 | KDM4E (0.66) | — | |
| SCHEMBL9370590 | 0.84 | KDM4E (0.67) | — | |
| SCHEMBL9666017 | 0.83 | KDM4E (0.60) | — | |
| SCHEMBL9370221 | 0.83 | KDM4E (0.62) | — | |
| SCHEMBL9212895 | 0.82 | ACAT1 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359197-B1 | ANTIHYPERCHOLESTEROLEMIC 4,5-DIARYL-2-SUBSTITUTED THIOIMIDAZOLES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-12-23 | — | — | EP | claimed |
| EP-0359197-A1 | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| US-4900744-A | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-13 | — | — | US | claimed |
| JP-2174762-A | — | — | None | — | — | JP | disclosed |
| US-5478830-A | Pyrazolo pyrimidines; inhibitors of acyl-coenzyme A and cholesterol acyltransferase; antihypercholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5364875-A | Anticholesterol agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| US-5358946-A | Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-25 | — | — | US | disclosed |
| US-5310748-A | Anticholesterol agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| US-5290801-A | Anticholesterol or antilipemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-03-01 | — | — | US | disclosed |
| WO-1993023381-A1 | IMIDAZOLES FOR THE TREATMENT OF ATHEROSCLEROSIS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023392-A1 | IMIDAZOLES LINKED TO BICYCLIC HETEROCYCLIC GROUPS FOR THE TREATMENT OF ATHEROSCLEROSIS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0359197-B1 | ANTIHYPERCHOLESTEROLEMIC 4,5-DIARYL-2-SUBSTITUTED THIOIMIDAZOLES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-12-23 | — | — | EP | disclosed |
| JP-H02174762-A | ANTI-HYPERCHOLSETEROLEMIA AGENT, 4,5-DIARYL-2-SUBSTITUTED THIOIMIDAZOLE | E I DU PONT DE NEMOURS & CO | 1990-07-06 | — | — | JP | disclosed |
| EP-0359197-A1 | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0359197-A1 | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| US-4900744-A | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-13 | — | — | US | disclosed |
| US-4900744-A | Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-13 | — | — | US | disclosed |