Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL28224034 | 0.82 | MAPT (0.53) | GAACYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9164429 | 0.78 | CTBP2 (0.49) | L3MBTL1PPID | |
| SCHEMBL6026832 | 0.78 | CYP2C19 (1.00) | GAACYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6026834 | 0.78 | CYP2C19 (1.00) | GAACYP2C19SMN1; SMN2MEN1KMT2A | |
| Toluene SCHEMBL9479143 | 0.75 | GAA (0.52) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| Benzene SCHEMBL28101102 | 0.74 | GAA (0.67) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL11233361 | 0.73 | SMN1; SMN2 (0.57) | GAACYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL124577 | 0.72 | KMT2A (0.59) | GAACYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6811621 | 0.71 | L3MBTL1 (0.57) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6811627 | 0.71 | L3MBTL1 (0.57) | GAASMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |