Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232408 | 0.94 | CYP3A4 (0.42) | CYP3A4MAPTGAAHPGDMEN1 | |
| SCHEMBL9160871 | 0.92 | CCR3 (0.36) | CYP3A4MAPTOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8828169 | 0.91 | OPRM1 (0.44) | CYP3A4MAPTGAAHPGDMEN1 | |
| SCHEMBL9160192 | 0.89 | CYP3A4 (0.38) | CYP3A4MAPTGAATHRBHPGD | |
| SCHEMBL9160658 | 0.87 | CNR1 (0.36) | — | |
| SCHEMBL9232815 | 0.85 | CNR1 (0.36) | SIGMAR1 | |
| SCHEMBL8828315 | 0.85 | OPRM1 (0.47) | CYP3A4MAPTALDH1A1OPRM1TMEM97 | |
| SCHEMBL9155180 | 0.84 | SIGMAR1 (0.42) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL9233122 | 0.82 | OPRM1 (0.42) | CYP3A4MAPTGAAHPGDMEN1 | |
| SCHEMBL9278700 | 0.81 | MAOB (0.39) | CYP3A4MAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430059-A | Treating heart disease | EISAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0633248-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0589491-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0399358-A2 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1990-11-28 | — | — | EP | disclosed |