Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.64 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15842559 | 0.84 | ALDH1A1 (0.51) | ALDH1A1HTTGAAMAPK1HPGD | |
| SCHEMBL5114485 | 0.80 | CA9 (0.60) | ALDH1A1MAPK1HPGDKDM4EMEN1 | |
| SCHEMBL3778775 | 0.79 | ALDH1A1 (0.75) | ALDH1A1HTTGAAMAPK1HPGD | |
| SCHEMBL4930754 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HTTGAAMAPK1HPGD | |
| SCHEMBL10847397 | 0.77 | MEN1 (0.54) | ALDH1A1MAPK1HPGDKDM4EMEN1 | |
| SCHEMBL10794104 | 0.75 | CA12 (0.50) | ALDH1A1MAPK1HPGDKDM4EMEN1 | |
| SCHEMBL10848826 | 0.75 | AR (0.50) | ALDH1A1GAAMAPK1HPGDKDM4E | |
| SCHEMBL2269457 | 0.75 | MAPT (0.43) | ALDH1A1MAPK1HPGDKDM4EMEN1 | |
| SCHEMBL10790754 | 0.75 | MCL1 (0.54) | ALDH1A1GAAHPGDHSD17B3KDM4E | |
| SCHEMBL115397 | 0.75 | HTR2B (0.64) | ALDH1A1MAPK1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359138-B1 | Stabilization and reduction of background fluorescence of hydroxy coumarin ester enzyme substrates | DU PONT (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5362627-A | Stabilization and reduction of background fluorescence of hydroxy coumarin ester enzyme substrates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0359138-A2 | Stabilization and reduction of background fluorescence of hydroxy coumarin ester enzyme substrates | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0111746-B1 | SULFONIC-ACID ESTERS OF HYDROXYCOUMARINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1987-09-16 | — | — | EP | disclosed |
| US-4618622-A | ANTIDEPRESSANTS, ANTIALLERGENS | BASF AKTIENGESELLSCHAFT (DE) | 1986-10-21 | — | — | US | disclosed |
| EP-0111746-A2 | Sulfonic-acid esters of hydroxycoumarines, their preparation and medicines containing them | BASF Aktiengesellschaft (DE) | 1984-06-27 | — | — | EP | disclosed |