SCHEMBL115397

SCHEMBL115397

CCc1cc(=O)c2c(O)cccc2o1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 15/20 0.64
HTR3A P46098 1/20 0.64
HTR2C P28335 4/20 0.60
AR P10275 3/20 0.54
MEN1 O00255 2/20 0.54
CYP3A4 P08684 2/20 0.54
MAPT P10636 2/20 0.54
KMT2A Q03164 2/20 0.54
ALDH1A1 P00352 1/20 0.54
CYP1A1 P04798 1/20 0.54
CYP1A2 P05177 1/20 0.54
PKM P14618 1/20 0.54
ALOX15 P16050 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
CYP1B1 Q16678 1/20 0.54
FTO Q9C0B1 1/20 0.54
RAF1 P04049 1/20 0.53
HPGD P15428 1/20 0.53
MAPK1 P28482 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12324852 0.83 HTR2B (0.64) HTR2BHTR3AHTR2CARMEN1
SCHEMBL5421595 0.80 RXRA (0.61) ARMEN1CYP3A4MAPTKMT2A
SCHEMBL17718333 0.80 HPGD (0.46) HTR2BHTR3AHTR2CMEN1KMT2A
SCHEMBL13718223 0.80 AR (0.54) HTR2BHTR3AHTR2CAR
SCHEMBL16972802 0.80 HTR2B (0.76) HTR2BHTR3AHTR2CARMEN1
SCHEMBL16972779 0.78 HTR2B (0.74) HTR2BHTR3AHTR2CARMEN1
SCHEMBL16972760 0.78 HTR2B (1.00) HTR2BHTR3AHTR2C
SCHEMBL24248100 0.78 POLH (0.56) HTR2BHTR3AHTR2CARMEN1
SCHEMBL2268224 0.77 SLC22A12 (0.47) HTR2BHTR3AHTR2CMAPK1
SCHEMBL31670262 0.77 MAPT (0.64) HTR2BHTR3AHTR2CARMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240067635-A1 CROMOLYN DERIVATIVES AND USES THEREOF THE GENERAL HOSPITAL CORPORATION 2024-02-29 US disclosed
US-11801316-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2023-10-31 US disclosed
US-11666669-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2023-06-06 US disclosed
US-20180193491-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2018-07-12 US disclosed
US-20180193492-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2018-07-12 US disclosed
US-20180169277-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2018-06-21 US disclosed
US-9925282-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2018-03-27 US disclosed
US-20160263257-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2016-09-15 US disclosed
US-9394288-B2 Compositions and methods for the treatment of asthma and allergy CELLIX BIO PRIVATE LIMITED (IN) 2016-07-19 US disclosed
US-20150126593-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ASTHMA AND ALLERGY CELLIX BIO PRIVATE LIMITED (IN) 2015-05-07 US disclosed
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION (US) 2014-05-22 US disclosed
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2012-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11801316-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC HTR2B 1832/4885HTR3A 700/4885HTR2C 2504/4885
US-20150126593-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ASTHMA AND ALLERGY LTA4H, LTC4S, ALOX5 HTR2B 1353/4885HTR3A 677/4885HTR2C 1221/4885
US-20240067635-A1 CROMOLYN DERIVATIVES AND USES THEREOF PRNP, HTT, CLN6 HTR2B 1850/4885HTR3A 793/4885HTR2C 3577/4885
US-20180193491-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC HTR2B 1832/4885HTR3A 700/4885HTR2C 2504/4885
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC HTR2B 1724/4885HTR3A 736/4885HTR2C 2539/4885
US-20160263257-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, CROCC, PSEN2 HTR2B 1831/4885HTR3A 757/4885HTR2C 2547/4885
US-20180193492-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC HTR2B 2108/4885HTR3A 797/4885HTR2C 2655/4885
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT CLN6, CA6, GALNT6 HTR2B 2326/4885HTR3A 1365/4885HTR2C 3160/4885
US-11666669-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC HTR2B 1724/4885HTR3A 736/4885HTR2C 2539/4885
US-20180169277-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC HTR2B 1832/4885HTR3A 700/4885HTR2C 2504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.