Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9156416 | 0.93 | DRD2 (0.40) | GPR119KDM4EPKMLMNAPIK3CD | |
| SCHEMBL9160117 | 0.93 | DRD2 (0.40) | GPR119KDM4EPKMLMNAPIK3CD | |
| SCHEMBL9161002 | 0.88 | YAP1 (0.44) | GPR119SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL9163267 | 0.86 | DRD2 (0.46) | GPR119KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL9157283 | 0.86 | DRD2 (0.46) | GPR119KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL9162378 | 0.86 | DRD2 (0.44) | GPR119KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL9163915 | 0.86 | DRD2 (0.44) | GPR119KDM4EKMT2AMEN1CYP2C19 | |
| SCHEMBL9160083 | 0.81 | YAP1 (0.44) | GPR119SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL3470001 | 0.76 | GFER (0.48) | SMN1; SMN2KDM4EPKMKMT2AMEN1 | |
| SCHEMBL9162351 | 0.76 | GFER (0.48) | SMN1; SMN2KDM4EPKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380355-B1 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0380355-A2 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4861771-A | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |