Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | GHSR | Q92847 | 5/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9160083 | 0.93 | YAP1 (0.44) | YAP1GHSRPRMT5LMNARAB9A | |
| SCHEMBL9156416 | 0.89 | DRD2 (0.40) | LMNAGPR119 | |
| SCHEMBL9160117 | 0.89 | DRD2 (0.40) | LMNAGPR119 | |
| SCHEMBL9162117 | 0.88 | GPR119 (0.44) | LMNASMN1; SMN2GPR119MEN1KMT2A | |
| SCHEMBL9162086 | 0.84 | DRD1 (0.52) | YAP1PRMT5LMNAGAAGPR119 | |
| SCHEMBL9157251 | 0.83 | YAP1 (0.44) | YAP1GHSRPRMT5ALOX15 | |
| SCHEMBL9163915 | 0.83 | DRD2 (0.44) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL9162378 | 0.83 | DRD2 (0.44) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL9157283 | 0.83 | DRD2 (0.46) | GPR119MEN1ALOX15KMT2A | |
| SCHEMBL9163267 | 0.83 | DRD2 (0.46) | GPR119MEN1ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380355-B1 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORP (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0380355-A2 | Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-Hydroxyphenyl)-2,3,4,5-tetra-hydro-1H-3-benzazepine as prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |