Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457806 | 0.82 | GAA (0.50) | DGAT1ROCK2POLBAPEX1GAA | |
| SCHEMBL28869675 | 0.80 | HDAC6 (0.47) | HDAC1HDAC6DGAT1POLBAPEX1 | |
| SCHEMBL27877878 | 0.79 | LCK (0.38) | HDAC1HDAC6DGAT1GAAKDM4E | |
| SCHEMBL9853614 | 0.76 | KEAP1 (0.45) | DGAT1ROCK2POLBAPEX1GAA | |
| SCHEMBL2323641 | 0.75 | DGAT1 (0.54) | DGAT1ROCK2KDM4EPARP1HPGD | |
| SCHEMBL811340 | 0.74 | DGAT1 (0.58) | DGAT1ROCK2KDM4EPARP1HPGD | |
| Ammonia Solution, Strong SCHEMBL10949233 | 0.74 | KEAP1 (0.44) | DGAT1ROCK2POLBAPEX1KDM4E | |
| SCHEMBL3344303 | 0.74 | DGAT1 (0.53) | DGAT1ROCK2PARP1PLAUMAPK8 | |
| SCHEMBL25060909 | 0.74 | GAA (0.50) | HDAC1HDAC6GAAKDM4EMPO | |
| Hydrochloric Acid SCHEMBL29810612 | 0.73 | DGAT1 (0.52) | DGAT1ROCK2KDM4EPARP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436368-A | Intermediates in the preparation of 4,5-difluoroanthranillic acid | PFIZER INC. (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0555283-B1 | INTERMEDIATES IN THE PREPARATION OF 4,5-DIFLUOROANTHRANILIC ACID | PFIZER (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0555283-A1 | INTERMEDIATES IN THE PREPARATION OF 4,5-DIFLUOROANTHRANILIC ACID. | PFIZER (US) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007822-A1 | INTERMEDIATES IN THE PREPARATION OF 4,5-DIFLUOROANTHRANILIC ACID | PFIZER INC. (US) | 1992-05-14 | — | — | WO | disclosed |