SCHEMBL9853614

SCHEMBL9853614

NC(=O)c1cc(F)c(F)cc1C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 2/20 0.45
NFE2L2 Q16236 1/20 0.45
DGAT1 O75907 1/20 0.45
KDM4E B2RXH2 3/20 0.41
ASPH Q12797 1/20 0.41
KDM8 Q8N371 1/20 0.41
PARP1 P09874 2/20 0.39
ALB P02768 1/20 0.39
ROCK2 O75116 1/20 0.39
AKR1C2 P52895 1/20 0.37
AKR1C1 Q04828 1/20 0.37
MAP2K2 P36507 1/20 0.36
MAP2K1 Q02750 1/20 0.36
KMT2A Q03164 4/20 0.35
GFER P55789 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
MEN1 O00255 3/20 0.35
TDP1 Q9NUW8 3/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL10949233 0.98 KEAP1 (0.44) KEAP1NFE2L2DGAT1KDM4EASPH
SCHEMBL4830274 0.87 KEAP1 (0.54) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL6068628 0.86 DGAT1 (0.50) KEAP1NFE2L2DGAT1KDM4EASPH
Lithium SCHEMBL30497778 0.85 KEAP1 (0.52) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL29045470 0.85 KEAP1 (0.52) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL11258908 0.85 ALDH1A1 (0.41) KEAP1KDM4EPARP1KMT2AGFER
SCHEMBL11702468 0.85 ALDH1A1 (0.41) KEAP1KDM4EPARP1KMT2AGFER
SCHEMBL10963459 0.85 ALDH1A1 (0.41) KEAP1KDM4EPARP1KMT2AGFER
SCHEMBL18079069 0.85 ALDH1A1 (0.41) KEAP1KDM4EPARP1KMT2AGFER
SCHEMBL27617170 0.85 ALDH1A1 (0.41) KEAP1KDM4EPARP1KMT2AGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4521616-A Method for the preparation of fluoroanthranilic acids OCCIDENTAL CHEMICAL CORPORATION (US) 1985-06-04 US claimed
US-4374267-A USED AS CHEMICAL INTERMEDIATES IN MAKING FLUORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 1983-02-15 US claimed
US-4343951-A Method for the preparation of fluoroaniline HOOKER CHEMICALS & PLASTICS CORP. (US) 1982-08-10 US claimed
WO-2025058977-A1 MODULATORS OF CORONAVIRUS 3C-LIKE PROTEASE AND USES THEREOF Vir Biotechnology, Inc. (US) 2025-03-20 WO disclosed
EP-0417445-A1 Single pot process for making a fluoroanthranilic acid OCCIDENTAL CHEMICAL CORPORATION (US) 1991-03-20 EP disclosed
US-4954639-A REACTING FLUOROPHTHALIC ACID COMPOUND WITH HYDROXYLAMINE OR SALT OCCIDENTAL CHEMICAL CORPORATION (US) 1990-09-04 US disclosed
EP-0055630-B1 METHOD FOR THE PREPARATION OF FLUOROPHTHALAMIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 1985-12-18 EP disclosed
US-4521616-A Method for the preparation of fluoroanthranilic acids OCCIDENTAL CHEMICAL CORPORATION (US) 1985-06-04 US disclosed
US-4374266-A USED AS CHEMICAL INTERMEDIATES IN MAKING FLUORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 1983-02-15 US disclosed
US-4374267-A USED AS CHEMICAL INTERMEDIATES IN MAKING FLUORINATED AROMATIC COMPOUNDS OCCIDENTAL CHEMICAL CORPORATION (US) 1983-02-15 US disclosed
US-4343951-A Method for the preparation of fluoroaniline HOOKER CHEMICALS & PLASTICS CORP. (US) 1982-08-10 US disclosed
EP-0055629-A1 Process for preparing fluoroanthranilic compounds HOOKER CHEMICALS & PLASTICS CORP. (US) 1982-07-07 EP disclosed
EP-0055630-A2 Method for the preparation of fluorophthalamic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1982-07-07 EP disclosed