Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9160110 | 0.88 | PTAFR (0.47) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL9160185 | 0.86 | OPRM1 (0.45) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828221 | 0.86 | OPRM1 (0.48) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828233 | 0.86 | OPRM1 (0.47) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828131 | 0.84 | CYP3A4 (0.52) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL9231260 | 0.83 | ABCB1 (0.44) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL9044237 | 0.83 | OPRM1 (0.44) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828147 | 0.83 | MAPT (0.56) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828235 | 0.83 | MAPT (0.56) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 | |
| SCHEMBL8828242 | 0.82 | OPRM1 (0.49) | OPRM1TMEM97SIGMAR1CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430059-A | Treating heart disease | EISAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0633248-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0589491-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |