Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163861 | 0.85 | CYP1A2 (0.49) | NAAASMN1; SMN2THRATHRBL3MBTL1 | |
| SCHEMBL9169739 | 0.85 | NAAA (0.56) | NAAAMAPK1POLBSMN1; SMN2THRA | |
| SCHEMBL9169965 | 0.85 | NAAA (0.56) | NAAAMAPK1POLBSMN1; SMN2THRA | |
| SCHEMBL9172050 | 0.85 | NAAA (0.56) | NAAAMAPK1POLBSMN1; SMN2THRA | |
| SCHEMBL9172331 | 0.81 | L3MBTL1 (0.48) | NAAASMN1; SMN2THRATHRBL3MBTL1 | |
| SCHEMBL9979317 | 0.80 | NAAA (0.71) | NAAASMN1; SMN2THRATHRBL3MBTL1 | |
| SCHEMBL1978767 | 0.80 | NAAA (0.71) | NAAASMN1; SMN2THRATHRBL3MBTL1 | |
| SCHEMBL9978782 | 0.80 | NAAA (0.71) | NAAASMN1; SMN2THRATHRBL3MBTL1 | |
| SCHEMBL9979011 | 0.80 | NAAA (0.71) | NAAASMN1; SMN2THRATHRBL3MBTL1 | |
| SCHEMBL6437809 | 0.80 | NAAA (0.71) | NAAASMN1; SMN2THRATHRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |