Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160629 | 0.92 | NLRP3 (0.62) | NLRP3GAAALDH1A1LMNACA1 | |
| SCHEMBL12462804 | 0.85 | KMT2A (0.53) | NLRP3ALDH1A1LMNACA1CA2 | |
| SCHEMBL2434886 | 0.82 | GAA (0.55) | NLRP3GAAALDH1A1LMNACA1 | |
| SCHEMBL9059808 | 0.81 | NLRP3 (0.47) | NLRP3GAAALDH1A1LMNAPOLB | |
| SCHEMBL31681252 | 0.80 | FFAR4 (0.57) | NLRP3ALDH1A1LMNACA2FFAR4 | |
| SCHEMBL2433650 | 0.79 | ALDH1A1 (0.51) | NLRP3GAAALDH1A1LMNACA1 | |
| SCHEMBL10884844 | 0.78 | TSHR (0.73) | GAAALDH1A1LMNACA1CA2 | |
| SCHEMBL25196007 | 0.77 | GBA1 (0.64) | NLRP3GAAALDH1A1LMNACA1 | |
| SCHEMBL8962523 | 0.77 | NLRP3 (0.50) | NLRP3ALDH1A1LMNACA9CA12 | |
| SCHEMBL27182555 | 0.77 | L3MBTL1 (0.46) | NLRP3LMNAPOLBL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5442060-A | Treating hyperlipemia, atherosclerosis | MITSUBISHI KASEI CORPORATION (JP) | 1995-08-15 | — | — | US | disclosed |
| EP-0591830-A1 | Carboxamide and urea derivatives having ACAT-inhibiting activityM | Mitsubishi Chemical Corporation (JP) | 1994-04-13 | — | — | EP | disclosed |