Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163857 | 0.94 | PLA2G2A (0.65) | PLA2G2ABLMCNR2CNR1LTA4H | |
| SCHEMBL9172248 | 0.91 | PLA2G2A (0.61) | PLA2G2ABLMCNR2CNR1LTA4H | |
| SCHEMBL9167589 | 0.87 | PLA2G2A (0.57) | PLA2G2ABLMCNR2CNR1LTA4H | |
| SCHEMBL9172080 | 0.85 | PLA2G2A (0.52) | PLA2G2ABLMCNR2CNR1ALDH1A1 | |
| SCHEMBL9172738 | 0.85 | PLA2G2A (0.53) | PLA2G2ABLMPPARGPLA2G4B | |
| SCHEMBL9163827 | 0.85 | PLA2G2A (0.54) | PLA2G2ABLMCNR2CNR1LTA4H | |
| SCHEMBL9170618 | 0.84 | PLA2G2A (0.53) | PLA2G2ABLMCNR2CNR1ALDH1A1 | |
| SCHEMBL9172280 | 0.84 | PLA2G2A (0.53) | PLA2G2ABLMCNR2LTA4H | |
| SCHEMBL9170589 | 0.83 | PLA2G2A (0.62) | PLA2G2ABLMCNR2CNR1ALDH1A1 | |
| SCHEMBL9162939 | 0.79 | FAAH (0.53) | CNR2CNR1ALDH1A1TSHRFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |