Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | C1R | P00736 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163849 | 0.84 | MAPT (0.39) | MAPTMEN1KMT2AALDH1A1PIN1 | |
| SCHEMBL9166566 | 0.84 | MAPT (0.43) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL9159576 | 0.83 | MAPT (0.40) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9163209 | 0.81 | MAPT (0.37) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27296771 | 0.81 | TP53 (0.39) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9158252 | 0.80 | MAPT (0.40) | POLBMAPTALDH1A1KDM4EHTT | |
| SCHEMBL9143575 | 0.80 | MAPT (0.38) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9163609 | 0.79 | HSD11B1 (0.39) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL202663 | 0.79 | POLB (0.51) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29381779 | 0.79 | POLB (0.51) | POLBMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028754-C | process for preparing quinoline derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-07 | — | — | CN | disclosed |
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |
| CN-1039416-A | Quinoline and preparation thereof and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1990-02-07 | — | — | CN | disclosed |