Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9166566 | 0.85 | MAPT (0.43) | MAPTNPBWR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9161086 | 0.83 | MEN1 (0.39) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9163849 | 0.82 | MAPT (0.39) | MAPTNPBWR1MEN1KMT2AALDH1A1 | |
| SCHEMBL27296771 | 0.82 | TP53 (0.39) | MAPTNPBWR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9164973 | 0.81 | POLB (0.44) | MAPTNPBWR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9159576 | 0.81 | MAPT (0.40) | MAPTNR1H4NPBWR1MEN1KMT2A | |
| SCHEMBL8834931 | 0.80 | SMN1; SMN2 (0.36) | MAPTSMN1; SMN2NPC1RAB9ACRHR1 | |
| SCHEMBL9164771 | 0.78 | PTGES (0.41) | MAPTMEN1KMT2APIN1HSD11B1 | |
| SCHEMBL9143575 | 0.76 | MAPT (0.38) | MAPTNPBWR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9159768 | 0.75 | MAPT (0.43) | MAPTNPBWR1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028754-C | process for preparing quinoline derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-07 | — | — | CN | disclosed |
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |
| CN-1039416-A | Quinoline and preparation thereof and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1990-02-07 | — | — | CN | disclosed |