Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KLK3 | P07288 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164973 | 0.80 | POLB (0.44) | MAPTLMNASMN1; SMN2PIN1ALDH1A1 | |
| SCHEMBL9159576 | 0.80 | MAPT (0.40) | MAPTHSD17B10LMNANR1H4PIN1 | |
| SCHEMBL10147924 | 0.80 | SMN1; SMN2 (0.45) | MAPTHSD17B10ELANETSHRSMN1; SMN2 | |
| SCHEMBL9164608 | 0.78 | ELANE (0.39) | LMNAELANESMN1; SMN2MGAMGAA | |
| SCHEMBL9166566 | 0.77 | MAPT (0.43) | MAPTLMNATSHRSMN1; SMN2GAA | |
| SCHEMBL9040983 | 0.76 | PKM (0.36) | MAPTHSD17B10LMNASMN1; SMN2PIN1 | |
| SCHEMBL10147919 | 0.76 | TSHR (0.46) | MAPTHSD17B10ELANETSHRSMN1; SMN2 | |
| SCHEMBL9164809 | 0.75 | HSD11B1 (0.41) | MAPTHSD17B10LMNASMN1; SMN2NR1H4 | |
| SCHEMBL10147928 | 0.74 | TSHR (0.45) | MAPTHSD17B10ELANETSHRSMN1; SMN2 | |
| SCHEMBL9164770 | 0.74 | HSD11B1 (0.40) | MAPTHSD17B10LMNASMN1; SMN2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028754-C | process for preparing quinoline derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-06-07 | — | — | CN | disclosed |
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| EP-0354994-A2 | Quinoline derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-21 | — | — | EP | disclosed |
| CN-1039416-A | Quinoline and preparation thereof and purposes | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1990-02-07 | — | — | CN | disclosed |