SCHEMBL9165451

SCHEMBL9165451

CCC(=O)Nc1ccc(Br)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TERT O14746 9/20 0.56
MAPT P10636 6/20 0.50
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
POLB P06746 4/20 0.50
ALDH1A1 P00352 4/20 0.50
RAB9A P51151 3/20 0.50
NPC1 O15118 2/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HPGD P15428 1/20 0.50
RXFP1 Q9HBX9 2/20 0.48
NSD2 O96028 1/20 0.48
BLM P54132 1/20 0.48
GAA P10253 2/20 0.47
DNMT1 P26358 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11143641 0.89 TERT (0.63) TERTMAPTMEN1KMT2APOLB
SCHEMBL5541185 0.84 TERT (0.57) TERTMAPTMEN1KMT2APOLB
SCHEMBL8604260 0.84 MAOA (0.65) TERTMAPTMEN1KMT2APOLB
SCHEMBL29159279 0.83 MEN1 (0.64) TERTMAPTMEN1KMT2APOLB
SCHEMBL8602265 0.81 MAOA (0.69) TERTMAPTMEN1KMT2APOLB
SCHEMBL13343618 0.81 TERT (0.53) TERTMAPTMEN1KMT2APOLB
SCHEMBL9511603 0.80 TERT (0.62) TERTMAPTMEN1KMT2APOLB
SCHEMBL9163040 0.79 MEN1 (0.53) TERTMAPTMEN1KMT2APOLB
SCHEMBL6366579 0.79 TERT (0.68) TERTMAPTMEN1KMT2APOLB
SCHEMBL1984615 0.78 MEN1 (0.70) MAPTMEN1KMT2APOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0353031-B1 Anthrapyridone compounds and their production process SUMITOMO CHEMICAL CO (JP) 1995-03-22 EP disclosed
US-5183892-A Used for coloring agent for synthetic resins and acid dyes; heat/light/sublimation and bleed resistance SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-02-02 US disclosed
EP-0353031-A2 Anthrapyridone compounds and their production process SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-01-31 EP disclosed
EP-0057665-B1 PROCESS FOR THE PREPARATION OF 1-ACYLAMINO-3,4-PHTHALOYL-ACRIDONES CIBA-GEIGY AG (CH) 1985-05-29 EP disclosed
US-4384119-A Catalytically reductive ring closure for 1-acylamino-3,4-phthaloylacridones CIBA-GEIGY CORPORATION (US) 1983-05-17 US disclosed
EP-0057665-A1 Process for the preparation of 1-acylamino-3,4-phthaloyl-acridones CIBA-GEIGY AG (CH) 1982-08-11 EP disclosed