Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328157 | 0.74 | AKT2 (0.44) | ALDH1A1GAAHSD17B10MAPTLMNA | |
| SCHEMBL2969026 | 0.65 | ESR1 (0.41) | KDM4EHPGDALDH1A1PLA2G10GAA | |
| SCHEMBL557663 | 0.64 | KDM4E (0.41) | KDM4EHPGDSMN1; SMN2ALDH1A1PLA2G10 | |
| SCHEMBL873201 | 0.61 | AKT2 (0.53) | KDM4EHPGDSMN1; SMN2ALDH1A1PLA2G10 | |
| SCHEMBL9453784 | 0.61 | MAPT (0.40) | SMN1; SMN2ALDH1A1GAAHSD17B10NPC1 | |
| SCHEMBL4457439 | 0.61 | KDM4E (0.42) | KDM4EHPGDSMN1; SMN2ALDH1A1PLA2G10 | |
| Biphenyl SCHEMBL7953731 | 0.60 | ALDH1A1 (0.75) | SMN1; SMN2ALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL9701635 | 0.59 | LMNA (0.50) | ALDH1A1HSD17B10MAPTLMNAL3MBTL1 | |
| SCHEMBL5145616 | 0.59 | LMNA (0.50) | ALDH1A1GAAHSD17B10MAPTLMNA | |
| SCHEMBL27619559 | 0.57 | LMNA (0.48) | ALDH1A1HSD17B10MAPTESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434164-A | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| EP-0240015-B1 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5008274-A | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0240015-A2 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-07 | — | — | EP | disclosed |