Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | STAT1 | P42224 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | BMP4 | P12644 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170467 | 0.91 | KDR (0.46) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9169606 | 0.90 | RAB9A (0.47) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9166749 | 0.89 | RAB9A (0.41) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9165874 | 0.88 | HSD17B1 (0.44) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9173628 | 0.87 | RAB9A (0.45) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9688673 | 0.86 | NPC1 (0.47) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9171209 | 0.86 | FYN (0.39) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9174113 | 0.85 | CYP11B1 (0.41) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9165447 | 0.85 | FYN (0.41) | KDRKMT2ANPC1RAB9AMAPT | |
| SCHEMBL9163418 | 0.85 | GAK (0.39) | KDRKMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420128-A | Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0503099-A1 | PYRIMIDINE DERIVATIVE, PRODUCTION THEREOF, AND ANDROGEN INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-09-16 | — | — | EP | disclosed |