Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.80 |
| ▸ | DRD4 | P21917 | 3/20 | 0.80 |
| ▸ | DRD2 | P14416 | 3/20 | 0.80 |
| ▸ | HTR1A | P08908 | 3/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9247812 | 0.89 | SIGMAR1 (1.00) | SIGMAR1DRD4DRD2 | |
| SCHEMBL9249152 | 0.88 | SIGMAR1 (1.00) | SIGMAR1DRD4DRD2HTR1AADRA1A | |
| SCHEMBL9248869 | 0.86 | SIGMAR1 (1.00) | SIGMAR1DRD4DRD2 | |
| SCHEMBL9163711 | 0.85 | SIGMAR1 (0.74) | SIGMAR1DRD4DRD2HTR1AADRA1A | |
| SCHEMBL9368511 | 0.79 | DRD4 (0.69) | SIGMAR1DRD4DRD2HTR1AADRA1A | |
| SCHEMBL14291709 | 0.79 | ABCB1 (0.80) | SIGMAR1DRD4DRD2 | |
| SCHEMBL4470096 | 0.79 | HTR1A (0.95) | DRD4DRD2HTR1AHTR7 | |
| SCHEMBL4463626 | 0.78 | HTR1A (1.00) | DRD2HTR1AHTR7 | |
| SCHEMBL9247478 | 0.78 | SIGMAR1 (1.00) | SIGMAR1DRD4DRD2HTR1AADRA1A | |
| SCHEMBL4458829 | 0.77 | DRD2 (1.00) | DRD2HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | claimed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | claimed |
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | disclosed |