Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.30 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5348858 | 0.85 | PNMT (0.51) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL6557715 | 0.85 | PNMT (0.47) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL9167880 | 0.84 | PNMT (0.36) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL5346821 | 0.83 | PNMT (0.51) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL5347439 | 0.83 | PNMT (0.51) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL9163417 | 0.82 | PNMT (0.37) | PNMTDRD2DRD4DRD3PGR | |
| SCHEMBL3994174 | 0.82 | PNMT (0.54) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL9170205 | 0.81 | MAP3K9 (0.31) | PNMTMAP3K9MAP3K11 | |
| SCHEMBL7677548 | 0.81 | PNMT (0.53) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL9170496 | 0.81 | PNMT (0.35) | PNMTMAP3K9MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420320-A | Method for preparing cyclopentadienyl-type ligands and metallocene compounds | PHILLIPS PETROLEUM COMPANY (US) | 1995-05-30 | — | — | US | disclosed |