Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4403788 | 0.88 | CA1 (0.42) | ALDH1A1LMNAKCNH2ALOX15 | |
| SCHEMBL5290292 | 0.87 | CHRNA7 (0.45) | ALDH1A1LMNAMAOBKDM4EPOLB | |
| Bromide SCHEMBL11580547 | 0.81 | PABPC1 (0.51) | ALDH1A1LMNACYP2D6L3MBTL1KDM4E | |
| Bromide SCHEMBL8857808 | 0.80 | CHKA (0.57) | ALDH1A1LMNACYP2D6RAB9AL3MBTL1 | |
| SCHEMBL13361704 | 0.78 | CA2 (0.43) | ALDH1A1LMNATP53KDM4EPOLB | |
| SCHEMBL13838215 | 0.78 | CHKA (0.53) | ALDH1A1LMNACYP2D6RAB9AMAOA | |
| SCHEMBL1525672 | 0.78 | ALDH1A1 (0.52) | ALDH1A1LMNARAB9AL3MBTL1TP53 | |
| Bromide SCHEMBL3312585 | 0.77 | CHRNA7 (0.57) | ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1250826 | 0.76 | ALDH1A1 (0.55) | ALDH1A1LMNARAB9AL3MBTL1TP53 | |
| Hydrochloric Acid SCHEMBL10935706 | 0.76 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2D6RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384232-A | Process for rapid access development of silver halide films using pyridinium as development accelerators | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-01-24 | — | — | US | claimed |