Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.57 |
| ▸ | RARB | P10826 | 3/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9324878 | 0.96 | PLA2G2A (0.70) | PLA2G2AKMT2AMEN1NR4A2TP53 | |
| SCHEMBL9325248 | 0.96 | PLA2G2A (0.70) | PLA2G2AKMT2AMEN1NR4A2TP53 | |
| SCHEMBL9325267 | 0.96 | PLA2G2A (0.70) | PLA2G2AKMT2AMEN1NR4A2TP53 | |
| SCHEMBL9325250 | 0.95 | PLA2G2A (0.68) | PLA2G2AKMT2AMEN1NR4A2PLA2G4B | |
| SCHEMBL2651146 | 0.90 | KMT2A (0.79) | PLA2G2AKMT2AMEN1NR4A2TP53 | |
| SCHEMBL31007012 | 0.88 | PLA2G2A (0.58) | PLA2G2AKMT2AMEN1NR4A2 | |
| SCHEMBL9167382 | 0.88 | PLA2G2A (0.58) | PLA2G2AKMT2AMEN1NR4A2 | |
| SCHEMBL9325255 | 0.88 | PLA2G2A (0.58) | PLA2G2AKMT2AMEN1NR4A2PLA2G4B | |
| SCHEMBL1776182 | 0.88 | MEN1 (0.75) | PLA2G2AKMT2AMEN1NR4A2TP53 | |
| SCHEMBL9170809 | 0.87 | PLA2G2A (0.82) | PLA2G2AKMT2ATP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |