Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31007012 | 1.00 | PLA2G2A (0.58) | PLA2G2ALMNAHPGDMEN1KMT2A | |
| SCHEMBL9323897 | 0.96 | PLA2G2A (0.54) | PLA2G2ALMNAHPGDMEN1KMT2A | |
| SCHEMBL9324877 | 0.96 | PLA2G2A (0.54) | PLA2G2ALMNAHPGDMEN1KMT2A | |
| SCHEMBL9325186 | 0.96 | PLA2G2A (0.54) | PLA2G2ALMNAHPGDMEN1KMT2A | |
| SCHEMBL9327294 | 0.95 | NR4A2 (0.55) | PLA2G2ALMNAHPGDMEN1KMT2A | |
| SCHEMBL2650902 | 0.91 | LMNA (0.60) | LMNAHPGDMEN1KMT2ASMPD1 | |
| SCHEMBL9327299 | 0.89 | SMPD1 (0.48) | PLA2G2ALMNAHPGDSMPD1NR4A2 | |
| SCHEMBL9323928 | 0.88 | LMNA (0.60) | LMNAHPGDMEN1KMT2ANR4A2 | |
| SCHEMBL9167771 | 0.88 | PLA2G2A (0.76) | PLA2G2AMEN1KMT2ANR4A2 | |
| SCHEMBL391547 | 0.88 | MEN1 (0.71) | LMNAHPGDMEN1KMT2ASMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |