Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.86 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.65 |
| ▸ | DRD1 | P21728 | 4/20 | 0.65 |
| ▸ | DRD3 | P35462 | 4/20 | 0.65 |
| ▸ | HTR2A | P28223 | 4/20 | 0.65 |
| ▸ | HTR2C | P28335 | 4/20 | 0.65 |
| ▸ | HRH1 | P35367 | 4/20 | 0.65 |
| ▸ | HTR2B | P41595 | 4/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817056 | 0.92 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| SCHEMBL13921290 | 0.87 | SETD7 (0.82) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| SCHEMBL9631147 | 0.84 | SETD7 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| SCHEMBL9215889 | 0.83 | HRH1 (0.89) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| SCHEMBL8877537 | 0.79 | SETD7 (0.73) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Pizotyline SCHEMBL8771138 | 0.79 | DRD1 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Pizotyline SCHEMBL29366884 | 0.79 | DRD1 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| SCHEMBL11521925 | 0.79 | SETD7 (0.73) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| Pizotyline SCHEMBL44122 | 0.79 | DRD1 (1.00) | SETD7CHRM2CHRM1ADRA1AKCNH2 | |
| SCHEMBL11780074 | 0.78 | CHRM2 (0.69) | SETD7CHRM2CHRM1ADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416087-A | Bis-benzo, cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use | SCHERING CORPORATION | 1995-05-16 | — | — | US | disclosed |
| WO-1992006970-A1 | BIS-BENZO CYCLOHEPTA PIPERIDYLIDENE, PIPERIDINE AND PIPERAZINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | SCHERING CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |