Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830812 | 0.88 | TACR1 (0.45) | TACR1TACR3TSHRCYP2C19CYP2C9 | |
| SCHEMBL2039023 | 0.86 | TACR1 (0.44) | TACR1TACR3CYP2C19MAPTSMN1; SMN2 | |
| SCHEMBL22211342 | 0.86 | TACR1 (0.44) | TACR1TACR3TSHRCYP2C19CYP2C9 | |
| SCHEMBL4809720 | 0.86 | TACR1 (0.55) | TACR1TACR3TSHRCYP2C19CYP2C9 | |
| SCHEMBL26679406 | 0.85 | TACR3 (0.57) | TACR1TACR3CYP2C19CYP3A4MAPT | |
| SCHEMBL8830633 | 0.84 | TACR1 (0.51) | TACR1TACR3TSHRCYP2C19CYP2C9 | |
| SCHEMBL8830792 | 0.84 | TACR1 (0.43) | TACR1TACR3MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL7792172 | 0.83 | TACR1 (0.42) | TACR1TACR3TSHRCYP2C19CYP2C9 | |
| SCHEMBL22211320 | 0.83 | TACR1 (0.42) | TACR1TACR3TSHRCYP2C19CYP3A4 | |
| SCHEMBL8830648 | 0.83 | GPR119 (0.45) | TACR1TACR3TSHRCYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2719695-B1 | AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND | KUREHA CORP (JP) | 2016-05-18 | — | — | EP | disclosed |
| US-9241488-B2 | Azole derivative, method for producing azole derivative, and intermediate compound | KUREHA CORPORATION (JP) | 2016-01-26 | — | — | US | disclosed |
| US-20140113815-A1 | AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND | KUREHA CORPORATION (JP) | 2014-04-24 | — | — | US | disclosed |
| EP-2719695-A1 | AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND | Kureha Corporation (JP) | 2014-04-16 | — | — | EP | disclosed |
| EP-0571267-B1 | Use of azole derivatives for the preparation of drugs useful for inhibiting the aromatase and treating of estrogen-dependent diseases | KUREHA CHEMICAL IND CO LTD (JP) | 1995-04-26 | — | — | EP | disclosed |
| US-5286737-A | Benzyl, cyclopentane azole derivatives | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1994-02-15 | — | — | US | disclosed |
| EP-0571267-A1 | Use of azole derivatives for the preparation of drugs useful for inhibiting the aromatase and treating of estrogen-dependent diseases | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-11-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140113815-A1 | AZOLE DERIVATIVE, METHOD FOR PRODUCING AZOLE DERIVATIVE, AND INTERMEDIATE COMPOUND | CBR3, CYP4F3, CYP4F11 | TACR1 1941/4885TACR3 406/4885TSHR 2474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.