Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT2 | O75908 | 1/20 | 0.54 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ICMT | O60725 | 2/20 | 0.51 |
| ▸ | ALB | P02768 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9162956 | 0.93 | EPHX2 (0.49) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL9171768 | 0.93 | SOAT2 (0.67) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL9171776 | 0.93 | SOAT2 (0.67) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL9417384 | 0.91 | SOAT2 (0.64) | SOAT2SOAT1MEN1KMT2AKDM4E | |
| SCHEMBL9417389 | 0.91 | SOAT2 (0.64) | SOAT2SOAT1MEN1KMT2AKDM4E | |
| SCHEMBL9621976 | 0.88 | HDAC3 (0.59) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL9621940 | 0.88 | HDAC3 (0.59) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL9621938 | 0.88 | HDAC3 (0.59) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL9417598 | 0.88 | EPHX2 (0.53) | SOAT2SOAT1LMNANPC1RAB9A | |
| SCHEMBL30020925 | 0.87 | LMNA (0.54) | SOAT2SOAT1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |