SCHEMBL91687

SCHEMBL91687

Cc1ccc(OC(=O)c2c(C)cc(C3CCC(C)CO3)cc2C)cc1C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.33
NR1H4 Q96RI1 2/20 0.32
RHEB Q15382 1/20 0.32
ADCY8 P40145 1/20 0.31
ADCY1 Q08828 1/20 0.31
LDHA P00338 1/20 0.31
DRD4 P21917 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL91712 0.90 CFTR (0.30)
SCHEMBL91708 0.86 SLC6A3 (0.33)
SCHEMBL91690 0.86 TAS1R3 (0.31)
SCHEMBL91768 0.81
SCHEMBL91686 0.80 KMT2A (0.32)
SCHEMBL91704 0.76 GRM2 (0.36)
SCHEMBL91828 0.75
SCHEMBL91783 0.75
SCHEMBL13863726 0.74
SCHEMBL14075250 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129002-B2 Compounds for use in liquid crystal media MERCK PATENT GMBH (DE) 2012-03-06 US disclosed