Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846107 | 0.86 | PDE3B (0.41) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL9846383 | 0.86 | PDE3B (0.43) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL9846304 | 0.83 | PDE3B (0.41) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL27352785 | 0.82 | PDE3B (0.43) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL9278136 | 0.81 | MAPT (0.51) | KDM4EMAPTPDE3BPDE3AGAA | |
| SCHEMBL27337641 | 0.81 | POLB (0.49) | KDM4EMAPTPDE3BPDE3AGAA | |
| SCHEMBL9283645 | 0.81 | MAPT (0.48) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL9168694 | 0.81 | PDE3B (0.42) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL9164330 | 0.80 | MAPT (0.41) | KDM4EMAPTAPAF1RECQLPDE3B | |
| SCHEMBL9846165 | 0.80 | PDE3B (0.41) | KDM4EMAPTAPAF1RECQLPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650362-A1 | ANTIVIRAL COMBINATIONS | GLAXO GROUP LIMITED (GB) | 1995-05-03 | — | — | EP | claimed |
| WO-1994002154-A1 | ANTIVIRAL COMBINATIONS | GLAXO GROUP LIMITED (GB) | 1994-02-03 | — | — | WO | claimed |
| EP-0484071-A2 | Synergism of HIV reverse transcriptase inhibitors | MERCK & CO. INC. (US) | 1992-05-06 | — | — | EP | claimed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | claimed |
| EP-0666744-A1 | USE OF BHAP COMPOUNDS IN COMBINATION WITH OTHER NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF HIV INFECTION | THE UPJOHN COMPANY (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0650362-A1 | ANTIVIRAL COMBINATIONS | GLAXO GROUP LIMITED (GB) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994009781-A1 | USE OF BHAP COMPOUNDS IN COMBINATION WITH OTHER NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF HIV INFECTION | THE UPJOHN COMPANY (US) | 1994-05-11 | — | — | WO | disclosed |
| WO-1994002154-A1 | ANTIVIRAL COMBINATIONS | GLAXO GROUP LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |
| EP-0484071-A2 | Synergism of HIV reverse transcriptase inhibitors | MERCK & CO. INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |