Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168694 | 0.94 | PDE3B (0.42) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9283645 | 0.84 | MAPT (0.48) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9278136 | 0.84 | MAPT (0.51) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9846212 | 0.83 | SLC2A1 (0.40) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9164330 | 0.82 | MAPT (0.41) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9846298 | 0.81 | PDE3B (0.38) | PDE3BPDE3AMAPTGAAMAPK1 | |
| SCHEMBL9846203 | 0.81 | PDE3B (0.38) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9170296 | 0.80 | KDM4E (0.44) | PDE3BPDE3AMAPTGAATSHR | |
| SCHEMBL9846107 | 0.79 | PDE3B (0.41) | PDE3BPDE3AMAPTGAALMNA | |
| SCHEMBL9680853 | 0.79 | MAPT (0.38) | MAPTGAALMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |