Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 13/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.39 |
| ▸ | PIK3R5 | Q8WYR1 | 13/20 | 0.39 |
| ▸ | PIK3R3 | Q92569 | 13/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9256845 | 0.93 | PIK3CD (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9173465 | 0.90 | ALDH1A1 (0.45) | CCNA2CDK2CCNA1F10 | |
| SCHEMBL9837911 | 0.82 | PIK3CD (0.33) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9522531 | 0.75 | MAPT (0.43) | — | |
| SCHEMBL9173375 | 0.72 | ALDH1A1 (0.51) | CCNA2CDK2CCNA1F10 | |
| SCHEMBL9172754 | 0.70 | PTGER1 (0.47) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9170672 | 0.70 | PIK3CD (0.42) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9170065 | 0.69 | ALDH1A1 (0.52) | CCNA2CDK2CCNA1 | |
| SCHEMBL9523022 | 0.69 | MAPT (0.42) | — | |
| SCHEMBL30433314 | 0.68 | TSHR (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5424308-A | Immunomodulating agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-06-13 | — | — | US | disclosed |
| EP-0422051-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012630-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347773-A1 | Condensed Pyrazole 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1989-12-27 | — | — | EP | disclosed |