Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417671 | 0.87 | NAAA (0.60) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL9169489 | 0.84 | L3MBTL1 (0.50) | NAAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9549318 | 0.81 | NAAA (0.67) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL11078107 | 0.79 | HTT (0.86) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL5362359 | 0.79 | HTT (0.86) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL11089468 | 0.79 | HTT (0.86) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL9260536 | 0.79 | HTT (0.86) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL9549393 | 0.79 | NAAA (0.63) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL11224330 | 0.77 | TSHR (0.71) | NAAATSHRHTTHPGDALDH1A1 | |
| SCHEMBL11035547 | 0.77 | TSHR (0.71) | NAAATSHRHTTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |