Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 12/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 12/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168308 | 0.91 | ALDH1A1 (0.62) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL7628788 | 0.87 | ALDH1A1 (0.60) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL2743840 | 0.82 | CHRM2 (0.54) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL1916246 | 0.82 | CHRM2 (0.56) | ALDH1A1MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL20148244 | 0.81 | ALDH1A1 (0.70) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL10411259 | 0.81 | HDAC1 (0.49) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL9816060 | 0.81 | HDAC1 (0.47) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL5253343 | 0.80 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL2743854 | 0.80 | ADRA1B (0.42) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL7951597 | 0.79 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2ACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4726304-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-20050048000-A1 | Amyloid targeting imaging agents and uses thereof | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-03-03 | — | — | US | claimed |
| US-6783731-B1 | FOR DETERMINING ACETAMINOPHEN IN BIOLOGICAL FLUIDS COMPRISING ENZYMES AND OTHER REAGENTS WHICH REMAIN ACTIVE WHEN COMBINED AND COATED IN DRY FORMAT AND WHICH GIVE A CLEAR AND PRECISE SIGNAL ON OXIDATIVE COUPLING WITH A SUITABLE COUPLER | ORTHO-CLINICAL DIAGNOSTICS, INC. | 2004-08-31 | — | — | US | claimed |
| JP-2003517458-A | — | — | 2003-05-27 | — | — | JP | claimed |
| EP-1303311-A2 | AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF | Neurochem, Inc. (CA) | 2003-04-23 | — | — | EP | claimed |
| EP-1276483-A2 | COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2003-01-22 | — | — | EP | claimed |
| US-20020115717-A1 | Amyloid targeting imaging agents and uses thereof | NEUROCHEM (INTERNATIONAL) LIMITED (GI) | 2002-08-22 | — | — | US | claimed |
| EP-0750197-B1 | Dry analytical element for acetaminophen assay | JOHNSON & JOHNSON CLIN DIAG (US) | 2002-04-24 | — | — | EP | claimed |
| WO-2002007781-A2 | AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF | NEUROCHEM INC. (CA) | 2002-01-31 | — | — | WO | claimed |
| EP-0580070-B1 | Dry analytical element for acetaminophen assay | JOHNSON & JOHNSON CLIN DIAG (US) | 2001-03-14 | — | — | EP | claimed |
| WO-2000064420-A2 | COMPOSITIONS AND METHODS FOR TREATING AMYLOIDOSIS USING SULPHONATE DERIVATIVES | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2000-11-02 | — | — | WO | claimed |
| US-6015683-A | SUPPORT WITH REAGENT LAYER COMPRISING ASCORBATE OXIDASE, TYROSINASE, OR LACCASE; AN ARYL ACYLAMIDASE; AND 1-(3-SULFOPROPYL)-1,2,3,4-TETRAHYDROQUINOLINE; FOR ACCURATE, RAPID QUANTITATIVE DETERMINATION IN AQUEOUS FLUIDS | CLINICAL DIAGNOSTIC SYSTEMS, INC. (US) | 2000-01-18 | — | — | US | claimed |
| EP-0750197-A2 | Dry analytical element for acetaminophen assay | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) | 1996-12-27 | — | — | EP | claimed |
| EP-0580070-A2 | Dry analytical element for acetaminophen assay | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1994-01-26 | — | — | EP | claimed |
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2014-11-06 | — | — | US | disclosed |
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2014-11-06 | — | — | US | disclosed |
| US-4672029-A | SENSITIVE AT LOW CONCENTRATIONS | EASTMAN KODAK COMPANY (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0184437-A2 | Color-forming couplers and their use in the analytical determination of hydrogen peroxide or other analytes | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1986-06-11 | — | — | EP | disclosed |
| EP-0168035-A2 | Use of anilin derivatives as coupling agents in oxidative colour-forming reactions | Roche Diagnostics GmbH (DE) | 1986-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050048000-A1 | Amyloid targeting imaging agents and uses thereof | APP, APBA1, BACE1 | DRD2 4032/4885DRD4 3652/4885DRD3 3595/4885 |
| US-20020115717-A1 | Amyloid targeting imaging agents and uses thereof | APP, APBA1, BACE1 | DRD2 4032/4885DRD4 3652/4885DRD3 3595/4885 |
| US-20140329746-A1 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | DRD2 4826/4885DRD4 4784/4885DRD3 4771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.