1,2-Dichlorobenzene

1,2-Dichlorobenzene

SCHEMBL9174409

C.Clc1ccccc1Cl.N=C=O.N=C=O

nearest known ligand 0.59

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.59
LMNA P02545 1/20 0.59
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
ALDH1A1 P00352 5/20 0.39
CYP2A6 P11509 4/20 0.36
CYP1A2 P05177 3/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
POLB P06746 1/20 0.36
HTR3E A5X5Y0 1/20 0.36
HTR3B O95264 1/20 0.36
HTR3A P46098 1/20 0.36
HTR3D Q70Z44 1/20 0.36
HTR3C Q8WXA8 1/20 0.36
PTPRC P08575 1/20 0.35
PNMT P11086 1/20 0.35
IDO1 P14902 1/20 0.35
MGLL Q99685 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1,2-Dichlorobenzene SCHEMBL727832 0.97 TSHR (0.62) TSHRLMNACES2CES1ALDH1A1
1,2-Dichlorobenzene SCHEMBL2713069 0.97 TSHR (0.62) TSHRLMNACES2CES1ALDH1A1
SCHEMBL10343329 0.83 PTPRC (0.52) TSHRLMNAALDH1A1CYP2A6MEN1
SCHEMBL30159729 0.83 PTPRC (0.52) TSHRLMNAALDH1A1CYP2A6MEN1
1,2-Dichlorobenzene SCHEMBL28243432 0.80
1,2-Dichlorobenzene SCHEMBL27469443 0.80
Chlorobenzene SCHEMBL28428700 0.80 TSHR (0.61) TSHRLMNACES2CES1CYP2A6
SCHEMBL2815413 0.79 TSHR (0.41) TSHRLMNACES2CES1ALDH1A1
SCHEMBL3734203 0.79 TSHR (0.41) TSHRLMNACES2CES1ALDH1A1
SCHEMBL10316768 0.79 LMNA (0.41) TSHRLMNACES2CES1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0561916-B1 MEMBRANE MADE FROM MULTIBLOCK POLYMER EXXON RESEARCH ENGINEERING CO (US) 1995-11-15 EP disclosed
EP-0563098-B1 MULTI-BLOCK POLYMER COMPRISING AN OXAZOLIDONE PREPOLYMER CHAIN EXTENDED WITH A COMPATIBLE SECOND PREPOLYMER, THE MEMBRANE MADE THEREFROM AND ITS USE IN SEPARATIONS EXXON RESEARCH ENGINEERING CO (US) 1995-04-05 EP disclosed
EP-0561916-A4 MEMBRANE MADE FROM MULTIBLOCK POLYMER 1993-11-24 EP disclosed
EP-0561916-A1 MEMBRANE MADE FROM MULTIBLOCK POLYMER. EXXON RESEARCH ENGINEERING CO (US) 1993-09-29 EP disclosed
US-5221481-A Thin film, high density membranes EXXON RESEARCH AND ENGINEERING COMPANY (US) 1993-06-22 US disclosed
US-5130017-A Of aromatic hydrocarbons from mixtures with monaromatics EXXON RESEARCH AND ENGINEERING COMPANY (US) 1992-07-14 US disclosed
WO-1992010276-A1 MULTI-BLOCK POLYMER COMPRISING AN OXAZOLIDONE PREPOLYMER CHAIN EXTENDED WITH A COMPATIBLE SECOND PREPOLYMER, THE MEMBRANE MADE THEREFROM AND ITS USE IN SEPARATIONS EXXON RESEARCH AND ENGINEERING COMPANY (US) 1992-06-25 WO disclosed
WO-1992010274-A1 MEMBRANE MADE FROM MULTIBLOCK POLYMER EXXON RESEARCH AND ENGINEERING COMPANY (US) 1992-06-25 WO disclosed
US-5098570-A Polyurea made from diisocyanate and diamine and a chain extender of a dianhydride and an epoxy, diisocyanate, polyester and diamine EXXON RESEARCH AND ENGINEERING COMPANY (US) 1992-03-24 US disclosed
US-5096592-A Of aromatic hydrocarbons from nonaromatic hydrocarbons EXXON RESEARCH AND ENGINEERING COMPANY (US) 1992-03-17 US disclosed
US-5049281-A Multi-block polymer comprising a first prepolymer, made by combining epoxy with diamine, chain extended with a compatible second prepolymer, the membrane made therefrom and its use in separations EXXON RESEARCH AND ENGINEERING COMPANY (US) 1991-09-17 US disclosed
US-5039422-A Separating aromatic hydrocarbons from nonaromatic hydrocarbons by selective permability under pervaporation or perstraction conditions EXXON RESEARCH AND ENGINEERING COMPANY (US) 1991-08-13 US disclosed
US-5039418-A Membrane made from a multi-block polymer comprising an oxazolidone prepolymer chain extended with a compatible second prepolymer and its use in separations EXXON RESEARCH AND ENGINEERING COMPANY (US) 1991-08-13 US disclosed
US-5039417-A Membrane made from a multi-block polymer comprising an imide or amide-acid prepolymer chain extended with a compatible second prepolymer and its use in separations EXXON RESEARCH AND ENGINEERING COMPANY (US) 1991-08-13 US disclosed