Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL879232 | 0.70 | HSD11B1 (0.53) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL18711711 | 0.70 | HSD11B1 (0.53) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL18478535 | 0.70 | HSD11B1 (0.53) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL18711710 | 0.70 | HSD11B1 (0.53) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL7797082 | 0.68 | MMP2 (0.37) | — | |
| SCHEMBL27905165 | 0.67 | CHRNB2 (0.42) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL14317238 | 0.66 | EPHX2 (0.55) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL21287989 | 0.65 | CHRNB2 (0.40) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL15218142 | 0.65 | CHRNB2 (0.40) | CHRNB2CHRNA3CHRNA4CHRNB4EPHX2 | |
| SCHEMBL1790270 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393746-A | Bone disorders | P&G PHARMACEUTICALS, INC. (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0586521-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021355-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |
| US-5137880-A | Treatment for osteoporosis, pagents disease arthritis | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0273514-B1 | NOVEL BICYCLIC DIPHOSPHONATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS | Norwich Eaton Pharmaceuticals, Inc. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4868164-A | OSTEOPOROSIS, ARTHRITIS | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0273514-A1 | Novel bicyclic diphosphonate compounds and pharmaceutical compositions | Norwich Eaton Pharmaceuticals, Inc. (US) | 1988-07-06 | — | — | EP | disclosed |