SCHEMBL917646

SCHEMBL917646

COCCOc1nc(Cl)nc(OCCOC)n1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 6/20 0.35
TSHR P16473 2/20 0.35
NUDT1 P36639 2/20 0.34
PLAU P00749 1/20 0.33
POLB P06746 3/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
HTT P42858 1/20 0.31
CYP1A2 P05177 1/20 0.31
ALDH1A1 P00352 1/20 0.30
ALOX15 P16050 1/20 0.30
MALT1 Q9UDY8 1/20 0.30
MAPK1 P28482 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8960380 0.95 TSHR (0.36) TLR7TSHRNUDT1PLAUPOLB
SCHEMBL25659408 0.88 TSHR (0.41) TLR7TSHRNUDT1POLBL3MBTL1
SCHEMBL12393233 0.88 TSHR (0.35) TLR7TSHRNUDT1PLAUMALT1
SCHEMBL14569431 0.86 CYP1A2 (0.42) TSHRPOLBL3MBTL1CA12CA1
SCHEMBL11138006 0.83 ALDH1A1 (0.47) TSHRPOLBCA12CA1CA2
SCHEMBL10002246 0.81 TSHR (0.37) TLR7TSHRNUDT1POLBL3MBTL1
SCHEMBL2735735 0.81 KDM4E (0.31) L3MBTL1
SCHEMBL11152744 0.79 TSHR (0.35) TLR7TSHRNUDT1PLAUPOLB
SCHEMBL5368019 0.79 PDE10A (0.41) TSHRPOLBL3MBTL1HTTCYP1A2
SCHEMBL27033804 0.78 RXRA (0.38) TLR7TSHRNUDT1PLAUPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153440-B2 Methods for altering surface characteristics of microspheres LUMINEX CORPORATION (US) 2012-04-10 US disclosed
US-20110086431-A1 Methods for Altering Surface Characteristics of Microspheres LUMINEX CORPORATION (US) 2011-04-14 US disclosed
US-7867774-B2 Methods for altering surface characteristics of microspheres LUMINEX CORPORATION (US) 2011-01-11 US disclosed
EP-1802973-B1 METHODS FOR ALTERING SURFACE CHARACTERISTICS OF MICROSPHERES LUMINEX CORP (US) 2010-05-05 EP disclosed
EP-1802973-A2 METHODS FOR ALTERING SURFACE CHARACTERISTICS OF MICROSPHERES Luminex Corporation (US) 2007-07-04 EP disclosed
WO-2006044275-A2 METHODS FOR ALTERING SURFACE CHARACTERISTICS OF MICROSPHERES LUMINEX CORPORATION (US) 2006-04-27 WO disclosed
US-20060078997-A1 Methods for altering surface characteristics of microspheres LUMINEX CORPORATION 2006-04-13 US disclosed