SCHEMBL917810

SCHEMBL917810

CCc1ccc2nc(S)sc2c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.65
SMN1; SMN2 Q16637 5/20 0.65
NPC1 O15118 5/20 0.65
TP53 P04637 3/20 0.45
MAPT P10636 7/20 0.44
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 1/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
HPGD P15428 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.44
KCNH2 Q12809 1/20 0.44
LMNA P02545 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
GAA P10253 1/20 0.40
MAPK1 P28482 1/20 0.40
APP P05067 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9016291 0.86 RAB9A (0.49) RAB9ASMN1; SMN2NPC1MAPTAPP
SCHEMBL1772237 0.86 NPC1 (0.47) RAB9ASMN1; SMN2NPC1TP53MAPT
SCHEMBL10383951 0.83 CASP3 (0.49) RAB9ASMN1; SMN2NPC1CYP1A2LMNA
SCHEMBL14557082 0.82 RAB9A (0.44) RAB9ASMN1; SMN2NPC1MAPTKDM4E
SCHEMBL8975913 0.82 APP (0.52) RAB9ASMN1; SMN2NPC1MAPTKDM4E
SCHEMBL14859131 0.81 CASP3 (0.45) RAB9ASMN1; SMN2NPC1
SCHEMBL10383965 0.81 CASP3 (0.45) RAB9ASMN1; SMN2NPC1
SCHEMBL2756575 0.80 RAB9A (0.67) RAB9ASMN1; SMN2NPC1TP53MAPT
SCHEMBL7601340 0.80 RAB9A (0.67) RAB9ASMN1; SMN2NPC1TP53MAPT
SCHEMBL10271447 0.80 SMN1; SMN2 (0.67) RAB9ASMN1; SMN2NPC1TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559587-B1 Agricultural or industrial tire with reinforced rubber composition GOODYEAR TIRE & RUBBER (US) 2008-08-20 EP claimed
US-20070187030-A1 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY 2007-08-16 US claimed
EP-1559587-A2 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-08-03 EP claimed
US-20040182486-A1 Agricultural or industrial tire with reinforced rubber composition BERNARD CARLO (LU) 2004-09-23 US claimed
CN-101965203-B Plasma sterilization indicator HOGY MEDICAL Co.,Ltd. (JP) 2014-10-15 CN disclosed
EP-2325242-B1 Rubber composition for cap tread and studless tire SUMITOMO RUBBER IND (JP) 2013-07-10 EP disclosed
US-20120259038-A1 RUBBER COMPOSITION FOR CAP TREAD AND WINTER TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-10-11 US disclosed
US-8222327-B2 Plasma sterilization indicator HOGY MEDICAL CO., LTD. (JP) 2012-07-17 US disclosed
EP-2325242-A1 Rubber composition for cap tread and studless tire Sumitomo Rubber Industries, Ltd. (JP) 2011-05-25 EP disclosed
US-20110112214-A1 RUBBER COMPOSITION FOR CAP TREAD AND STUDLESS TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2011-05-12 US disclosed
CN-101965203-A Plasma sterilization indicator HOGY MEDICAL CO LTD (JP) 2011-02-02 CN disclosed
US-20110009535-A1 PLASMA STERILIZATION INDICATOR HOGY MEDICAL CO., LTD. (JP) 2011-01-13 US disclosed
EP-0207737-B1 PROCESS FOR THE STABILIZATION OF MERCAPTOBENZOTHIAZOLE IN A LUBRICATING OIL COMPOSITION EXXON RESEARCH AND ENGINEERING COMPANY (US) 1990-12-19 EP disclosed
US-4946585-A USING MERCAPTOBENZOTHIAZOLE AMERICAN CYANAMID COMPANY (US) 1990-08-07 US disclosed
EP-0207737-A2 Process for the stabilization of mercaptobenzothiazole in a lubricating oil composition EXXON RESEARCH AND ENGINEERING COMPANY (US) 1987-01-07 EP disclosed
US-4589991-A FORMING AN AMINE SALT OF MERCAPTOBENZOTHIAZOLE, DISSOLVING IN AROMATIC ETHER SOLVENT EXXON RESEARCH & ENGINEERING CO. (US) 1986-05-20 US disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed
US-4431813-A HEATING 2-HALOANILINES AND AN ALKALI OR ALKALINE EARTH METAL XANTHATE IN A POLAR APROTIC SOLVENT HOECHST A.G. (DE) 1984-02-14 US disclosed
EP-0035219-B1 PROCESS FOR THE PREPARATION OF 2-MERCAPTOBENZTHIAZOLES HOECHST AKTIENGESELLSCHAFT (DE) 1983-03-02 EP disclosed
EP-0035219-A1 Process for the preparation of 2-mercaptobenzthiazoles HOECHST AKTIENGESELLSCHAFT (DE) 1981-09-09 EP disclosed